Lack of quality sleep is a global health issue, with 30–35% of the world’s population reporting that they experience insomnia symptoms. Poor sleep quality can affect us in many ways, contributing to health issues and impacting our productivity at work or school. The good news is that there are numerous ways to overcome sleeplessness.
For some people struggling with sleeplessness, antihistamines can provide occasional relief. While some antihistamines are available over-the-counter, most of those used as off-label sleep aids require a prescription.
Learn how to safely purchase a prescription antihistamine for sleep online to get the appropriate treatment quickly.
How To Get an Antihistamine Prescribed for Sleep
Before taking any sleep aid, you should consult a sleep expert. This kind of specialist can provide a comprehensive evaluation of your sleep patterns and identify the underlying causes of your sleep issues.
With less than 1% of healthcare professionals specializing in sleep medicine, that’s easier said than done. However, telemedicine clinics let you connect with sleep experts almost instantly from the comfort of your home.
Online clinics facilitate virtual consultations, eliminating long waiting and travel times. After a thorough evaluation, and if your doctor deems it appropriate, they may prescribe a specific antihistamine for sleep.
Kick, an online performance medicine clinic, offers a unique sleep program that connects you with experts who can help you receive the much-needed treatment in the shortest time possible.
Source: Yan Krukau
Kick—Your Partner in Achieving Better Sleep
Designed by a Stanford specialist, Dr. Alex Dimitriu, Kick’s program offers a selection of sleep medications tailored to your specific needs, including antihistamines like hydroxyzine. Other medications you can get from Kick are:
Besides medications, the program includes tips based on cognitive behavioral therapy for insomnia (CBT-i) best practices to help you get an all-encompassing treatment and reach a lasting solution for sleepless nights.
Other essential features include:
- Two trial medications to rotate in the first two weeks to reduce the risk of dependence
- Regular consultations to track progress and make necessary adjustments
- Delivery of the drugs to your doorstep or local pharmacy (the latter even available as a same-day service)
Kick’s sleep program has numerous positive reviews on Trustpilot, attesting to its effectiveness in helping patients overcome insomnia.
How To Join Kick
To join Kick’s program, follow three simple steps:
- Navigate to the signup page to initiate your 15-minute sleep visit
- Fill us in on your sleep issues and health history
- Add your payment and delivery information
Our team will assess your case and get back to you in 24 hours. If Kick isn’t the best solution for your specific issue, you won’t pay for the initial consultation, according to our Doctor Guarantee.
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Common Antihistamines You Can Take for Sleep
Four antihistamines typically prescribed to people with sleep issues are:
- Hydroxyzine
- Benadryl (Diphenhydramine)
- Doxylamine
- Chlorpheniramine
Hydroxyzine
Hydroxyzine, a first-generation antihistamine, is typically prescribed to individuals with the following conditions:
- Itching (caused by allergies)
- Hives (caused by allergies)
- Contact dermatitis (caused by allergies)
- Insomnia—off-label use
Once absorbed into the body, this drug blocks H1 histamine receptors in the brain while also increasing serotonin levels. The combined effects include reduced anxiety and increased drowsiness, which can promote sleep. Hydroxyzine is available as capsules, tablets, oral solutions, and injections.
The drug comes in in four doses:
- 10 mg
- 25 mg
- 50 mg
- 100 mg
The typical dose for sleep is 25mg in tablet form, taken an hour before bedtime.
Like other antihistamines, hydroxyzine is meant for short-term or occasional sleeplessness, and individuals with chronic insomnia may require more comprehensive treatment.
Benadryl (Diphenhydramine)
Benadryl, or diphenhydramine, suppresses the histamine activity of H1 receptors while inducing a sedative effect, making it a viable option for short-term treatment of insomnia.
The medication is available over-the-counter and is typically taken orally. It’s available in several forms and comes in two doses:
- 25 mg
- 50 mg
The usual dose for adults with sleep issues is 50 mg, but healthcare providers may recommend lower starting doses for people with mild insomnia.
Doxylamine
Doxylamine is another first-generation antihistamine, and it’s commonly used to manage symptoms of allergies and the common cold, such as:
- Sneezing
- Runny nose
- Watery eyes
- Itching
It can also be used off-label for short-term treatment of insomnia.
Once ingested, the drug blocks H1 histamine receptors in the brain, reducing the effects of histamine. It also has anticholinergic properties that contribute to its sedative effects.
Doxylamine is available over-the-counter in the U.S., but you should consult your healthcare provider if you intend to take it for sleep. The starting dose for adults with insomnia is 25 mg, and the medication is typically taken only for a short time.
Chlorpheniramine
Chlorpheniramine is typically used to treat symptoms of allergic conditions like rhinitis (hay fever). It’s available over-the-counter and is taken orally.
The drug is available in several forms and doses, including the following:
- Syrup—2 mg/5 mL
- Regular tablet—4 mg
- Extended-release tablet—12 mg
The typical dose for insomnia is a 4 mg tablet, taken before bed.
Side Effects of Antihistamines
Source: Andrew Patrick
While antihistamines can be effective for sleep, they carry the risk of unwanted reactions, which typically occur when patients don’t follow their doctor’s instructions. Check out the table below for a breakdown of the common side effects of these medications:
These lists aren’t exhaustive. If you experience any adverse reactions while on these medications, inform your doctor immediately.
Who Should and Shouldn’t Use Antihistamines for Sleep?
Adults experiencing issues with their sleep patterns can take antihistamines as a short-term solution. Still, these medications aren’t suitable for everyone.
Individuals with the following conditions should avoid taking antihistamines for sleep:
- People with severe liver impairment—Antihistamines are metabolized in the liver. Liver damage can slow down this process, leading to higher levels of the drug in the body
- Individuals with kidney disease—Renal disease may slow down the elimination of antihistamines, leading to various health complications
- People taking certain medications—These drugs may interact with other medicines, such as monoamine oxidase inhibitors (MAOIs), opioid pain medications, and certain antidepressants, increasing the risk of adverse effects
- Patients with a history of certain conditions—People with diabetes, enlarged prostate, epilepsy, heart disease, high blood pressure, glaucoma, and overactive thyroid may be negatively affected by antihistamines
- Pregnant or breastfeeding women—Antihistamines should be used with caution during pregnancy and breastfeeding
- Older adults—These medications can cause confusion, dizziness, and drowsiness in older adults
This list isn’t exhaustive. If you have other health conditions or use specific substances, inform your doctor before taking an antihistamine for sleep.
Tips for Taking Antihistamines for Sleep
To benefit from antihistamines, you should take them as prescribed by your healthcare provider. If you miss a dose, take the drug as soon as you remember unless it’s close to the time for your next dose. In that case, skip it and continue with the regular schedule. Other guidelines to follow include:
- Take the medication at the appropriate time—Antihistamines for sleep should be taken about an hour before you plan to go to bed to let the medication kick in on time
- Sleep for the recommended duration—Allocate 7–9 hours to sleep so that the sedative effects can subside by the time you wake up, preventing next-day drowsiness
- Avoid long-term use—Antihistamines are intended for short-term or occasional use since prolonged use can lead to tolerance
- Limit alcohol and caffeine—These substances can interfere with the sedative effects of antihistamines and disrupt your sleep cycle. If you take alcohol, avoid taking antihistamines for sleep that day
- Limit screen time before bed—The blue light emitted by electronic devices can affect your body’s natural sleep-wake cycle, making it harder to fall asleep. Turn off these devices at least an hour before going to bed
- Consult your healthcare provider—If you’re considering taking an antihistamine for sleep, discuss this with your healthcare provider first. They’ll design the most effective treatment based on your specific health conditions and any other substances you take
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Alternatives to Antihistamines for Sleep
If the risks of taking antihistamines for sleep outweigh the benefits, your doctor may recommend other sleep aids, which can fall into two categories:
- Sleep medications
- Non-pharmaceutical methods
Sleep Medications
If you’re not the best candidate for antihistamines, your doctor may recommend other drugs. Check out the table below for a detailed breakdown of common sleep medicines:
Non-Pharmaceutical Methods
Non-pharmaceutical methods can be effective for individuals experiencing chronic sleeplessness. They can be used as alternatives or in addition to medication, helping you reach a long-lasting solution. Some of them are:
- Relaxation techniques—Methods like progressive muscle relaxation, deep breathing, and meditation can help you manage stress and wind down before bed
- Regular exercise—Regular physical activity can help you fall asleep faster and enjoy deeper sleep. However, be careful not to exercise too close to bedtime since this might interfere with your sleep
- Healthy sleep habits—These include keeping a consistent sleep schedule, creating a quiet environment, and avoiding heavy meals, caffeine, and alcohol close to bedtime
To benefit from these methods, you should apply them regularly and consistently.
Featured image source: Kampus Production
